Can thieves break into home safe?

Could you elaborate on the potential risks of home safes being targeted by thieves? I'm curious to understand the security measures that might be bypassed, the types of tools or techniques that could be used, and whether certain types of safes are more vulnerable than others. Are there any specific safety features or precautions homeowners should consider to minimize the risk of a break-in? Additionally, how should one respond if they suspect their safe has been tampered with or broken into? I'd appreciate a concise yet comprehensive answer that addresses these key points.